Team Leader - Process R & D
Aurigene Pharmaceutical Services LimitedHyderabad, Republic Of India, IN18 hours ago
Job descriptionEducation : PhD in Organic Chemistry with 10 + years of experience (Mandatory) Business / Domain Understanding : Strong grasp of CDMO workflows, client expectations, IP awareness, and drug discovery / development interfaces (non-GMP to GMP handoffs). Plan and distribute daily / weekly experimental work, track plans vs. actuals and de-risk critical path tasks. Review and interpret complex analytical datasets (e.G., HPLC / UPLC, GC, LC–MS, NMR) for mass balance, assay, purity, and chiral integrity; Coordinate with SCM, ARD, SHE, and E&M to align material availability, method readiness, safety clearances, and equipment uptime. Forecast and ensure timely procurement of raw materials, solvents, and consumables with suitable alternates. Anticipate chemistry and scale-up risks; Map impurity genesis, fate, and purge; Improve routes for safety, robustness, and COGS (e.G., step telescoping, solvent swaps, greener reagents, reduced PMI / E-factor). Develop crystallization strategies (solvent / anti-solvent screening, seeding, supersaturation control) for polymorph selectivity and particle-size control; Provide day-to-day scientific mentorship; Build team competencies in key unit operations (e.G., hydrogenations, low-temperature chemistry, moisture / air-sensitive handling, continuous / flow where applicable). Enforce GLP / SLP, PPE compliance, chemical hygiene, waste segregation, and instrument calibration; Escalate instrument downtime, safety hazards, or deviations impacting delivery or safety to the Group Leader promptly. Prepare high-quality technical updates, data packages, and final dossiers with clear narratives, risks, and mitigation plans. Lead / participate in client calls; Support proposals with feasible synthetic routes, preliminary control strategies, and realistic costing / throughput estimates within required TAT. Comply fully with SHE guidelines; Drive continuous improvement via incident / near-miss analysis, CAPA implementation, and periodic safety audits. Create a collaborative, high-performance environment with clear objectives and feedback. Identify training needs, develop skill matrices and IDPs, and ensure completion of mandatory training. Ensure smooth administration and adherence to organizational policies and procedures. Technical Expertise : Deep command of synthetic organic chemistry, route scouting, and lab-to-pilot scale-up principles. Analytical Literacy : Proficient interpretation of NMR, LC–MS, HPLC / UPLC, GC, KF, and related in-process controls to drive decisions. Literature and IP : Expert use of Reaxys and SciFinder; Software and Documentation : Proficient in Word, PowerPoint, Excel; Leadership : Proven ability to lead and develop 7–10 scientists / RAs; Communication : Clear scientific writing and presentation for internal stakeholders and external clients. Problem Solving : Hypothesis-driven experimentation, DoE mindset, and data-driven optimization with clear acceptance criteria.
Role Overview
- Position Title : Team Leader - Process R&D
- Role Band : L1
- Location : Hyderabad
Purpose : Lead the design, development, and scale-up of safe, robust, and cost-efficient chemical processes that meet client specifications for quality, yield, and timelines.
Objective : Ensure on-time delivery with scientific rigor, data-driven decision-making, and measurable value addition across route selection, optimization, and tech transfer.
Minimum Requirements
Areas of Responsibilities (AOR)
AOR 1 : Project Execution and Delivery
ensure data integrity and scientific traceability.
AOR 2 : Process Development, Troubleshooting, and Value Addition
resolve issues using literature (Reaxys, SciFinder) and structured experimentation (e.G., DoE, mechanistic probes).
implement control strategies via reagent / solvent selection, stoichiometry, temperature profiles, and workup design.
minimize column chromatography.
AOR 3 : Team and Laboratory Management
conduct technical reviews and ensure high-quality ELN documentation.
maintain audit readiness.
AOR 4 : Client Communication and Proposal Preparation
communicate progress, deviations, and next-step experiments with timeline and resource implications.
AOR 5 : Safety, Health, and Environment (SHE)
conduct risk assessments (e.G., thermal / pressure hazards), and define safe operating spaces.
AOR 6 : People Management
Required Knowledge and Skills
strong patent and prior-art orientation for route / source ability.
disciplined ELN practices and data management.
strong prioritization and resource levelling.
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Team Leader • Hyderabad, Republic Of India, IN
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