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▷ Apply Now : Deputy General Manager (DGM) / Assistant General Manager (AGM) – Upstream Production (A

▷ Apply Now : Deputy General Manager (DGM) / Assistant General Manager (AGM) – Upstream Production (A

Symbiotec Pharmalab Pvt. Ltd.Indore, Madhya Pradesh, India
9 hours ago
Job description

Key Responsibilities :

Production & Operations Management :

  • Manage end-to-end upstream processes including chemical reactions, crystallization, solvent recovery, and work-up operations.
  • Plan and execute daily production activities to meet output, quality, and yield targets.
  • Monitor critical process parameters (CPPs) and ensure adherence to process design and safety.

Compliance & Documentation :

  • Ensure GMP compliance, and adherence to regulatory and safety guidelines (USFDA, EDQM, TGA, WHO).
  • Review and approve Batch Manufacturing Records (BMRs), SOPs, Deviation Reports, and Change Controls related to upstream activities.
  • Prepare and support regulatory audits, customer audits, and internal inspections.
  • People & Resource Management :

  • Lead and develop a team of shift engineers, supervisors, and operators.
  • Schedule manpower, oversee training and ensure adherence to SOPs and safety practices.
  • Foster a culture of accountability, teamwork, and continuous improvement.
  • Process & Quality Improvement :

  • Collaborate with R&D, Technology Transfer, and QA / QC teams to ensure smooth tech transfer and scale-up of new products.
  • Drive process optimization to improve yield, reduce cycle time, and minimize solvent loss.
  • Lead investigation of deviations, process failures, and implement corrective actions.
  • Plant & Equipment Oversight :

  • Oversee the operation and maintenance of key upstream equipment :
  • Reactors (GLR / SSR), condensers, scrubbers, distillation units, receivers, etc.
  • Coordinate with the Engineering team for preventive maintenance and equipment validation.
  • Inventory & Cost Control :

  • Monitor raw material consumption, solvent usage, and utility consumption.
  • Drive cost-reduction initiatives without compromising quality or compliance.
  • Key Skills and Competencies :

  • Deep understanding of chemical reaction engineering and process safety.
  • Expertise in hazardous reaction handling, including exothermic and pressure reactions.
  • Sound knowledge of GMP, cGMP, ICH, and regulatory requirements.
  • Strong leadership, team management, and problem-solving abilities.
  • Proficiency in production software (e.g., SAP, DCS, MES) is an added advantage.
  • Educational Qualifications :

  • B.E. / B.Tech in Chemical Engineering or equivalent OR M.Sc. in Chemistry / Organic Chemistry / Industrial Chemistry
  • Experience Required :

    15+ years of progressive experience in API manufacturing, with significant expertise in upstream operations including reaction handling, crystallization, and phase separation.

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    Deputy General Manager • Indore, Madhya Pradesh, India

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