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Scientist - Upstream Cell Culture, Bioprocess Design Center (Single-Use Facility)

Scientist - Upstream Cell Culture, Bioprocess Design Center (Single-Use Facility)

ConfidentialHyderabad / Secunderabad, Telangana
30+ days ago
Job description

Responsibilities :

  • Develop and optimize upstream cell culture processes, including media formulation, feeding strategies, and bioreactor control parameters.
  • Perform small-scale, bench-scale, and pilot-scale experiments to support process development and solving.
  • Assess and incorporate single-use bioreactor systems and technologies to enhance process flexibility and efficiency.
  • Design and complete experiments to enhance cell growth, productivity, and product quality attributes.

Technology Transfer and Scale-Up

  • Lead upstream process technology transfer to clinical and commercial manufacturing scales.
  • Develop and document detailed process descriptions, standard operating procedures (SOPs), and batch records for scale-up activities.
  • Collaborate with manufacturing to ensure smooth implementation of upstream processes in single-use production systems.

    • Data Analysis and Documentation

  • Analyze experimental data to evaluate process performance, identify trends, and recommend improvements.
  • Prepare technical reports, presentations, and documentation for internal and external collaborators, following Good Documentation Practices (GDP).
  • Maintain accurate records of process development activities and experimental results in electronic lab notebooks (ELNs).

    • Collaboration and multi-functional Support

  • Work closely with downstream processing, analytical development, quality assurance, and regulatory teams to ensure seamless integration into end-to-end biomanufacturing workflows.
  • Participate in project meetings and contribute to strategy discussions, ensuring alignment with organizational goals and timelines.
  • Support solving and resolution of upstream-related challenges during production.
  • Stay informed on advancements in cell culture technologies, single-use systems, and bioprocessing methodologies.
  • Identify and implement innovative approaches to improve upstream process efficiency, scalability, and sustainability.
  • Actively contribute to fostering a culture of innovation and continuous improvement within the Bioprocess Design Center.

    • Experience :

  • Ph.D., M.S., or B.S. in Biotechnology, Biochemical Engineering, Molecular Biology, or a related field with a focus on cell culture and upstream processing.
  • 3+ years of experience in upstream process development for biologics, including hands-on experience with mammalian or microbial cell culture systems.
  • Proficiency in working with single-use bioreactor systems is highly preferred.
  • Familiarity with fed-batch, perfusion, and continuous culture processes.
  • Solid understanding of bioreactor design, operation, and process control strategies.
  • Proficiency with process monitoring tools and analytical instrumentation for cell culture.
  • Excellent problem-solving and analytical skills with the ability to manage sophisticated data sets.
  • Strong written and verbal communication skills, with experience communicating technical data to diverse audiences.
  • Experience with cGMP guidelines, regulatory standards, and technology transfer in biomanufacturing.
  • Knowledge of cell line development and characterization.
  • Familiarity with automation, PAT (Process Analytical Technology), and data-driven optimization tools.
  • Lead numerous projects simultaneously and meet aggressive timelines.
  • Demonstrated ability to lead multiple collaborators and conflicting goals.
  • Business-level proficiency in English (verbal / written) and proficiency in Excel and presentation skills.
  • Willingness to travel as required.
  • Self-motivated, team-oriented, collaborative and skilled in working in a matrixed and multi-functional environment
  • Good social skills (oral and written)

    • Skills Required

    Biotechnology, biochemical engineering

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    Scientist • Hyderabad / Secunderabad, Telangana