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In Meril life sciences Pvt. Ltd. (Micro CRISPR) , particularly in biomanufacturing, upstream and downstream refer to the two main stages of producing biotechnology products, such as vaccines, proteins, and cell therapies. Job roles in these areas are distinct and require specialized skills.

Upstream job description

Upstream bioprocessing focuses on the initial phases of production, including cell culture development, fermentation, and growth optimization. Professionals in these roles work with living cells to produce the desired biological product.

General responsibilities

• Cell culture and fermentation : Cultivate and grow microbial or mammalian cell lines in bioreactors under controlled conditions to maximize product yield.
• Process development : Develop and optimize upstream processes, including selecting the right cell line and culture media, to ensure product quality and consistency.
• Bioreactor operations : Set up, operate, and maintain laboratory-scale and pilot-scale bioreactors, and monitor key parameters such as temperature, pH, and dissolved oxygen.
• Harvest and clarification : Collect and prepare the harvested material from the bioreactor for the downstream purification stage, which may involve filtration.
• Experimentation : Conduct small-scale studies and experiments to support process development and technology transfer.
• Documentation and compliance : Document all experimental data in electronic lab notebooks (ELNs) and ensure all processes adhere to regulatory and good manufacturing practice (GMP) guidelines.

Key skills and qualifications

Downstream job description

Downstream bioprocessing handles the recovery and purification of the desired product from the cell culture harvest produced during the upstream phase. These roles are focused on creating a pure and safe final product.

General responsibilities

Key skills and qualifications