RNA Delivery Formulation Discovery and Characterization Scientist

We are looking for both junior and senior scientists to join our team and contribute to the development of our novel mRNA-based vaccines and therapeutics. The ideal candidates will have experience in nucleic acid delivery systems, particularly focusing on lipid or polymer-based formulations, and will work on advancing our platform for efficient, long-term mRNA stability and delivery. The role will involve formulation discovery, microfluidics, particle size analysis, and nucleic acid quantification in a collaborative, fast-paced environment.

Key Responsibilities :

• Design, develop, and optimize lipid nanoparticle (LNP) or polymeric formulations for nucleic acid delivery (RNA or DNA), with a focus on mRNA.
• Conduct microfluidics experiments to synthesize, encapsulate, and characterize lipid or polymeric nanoparticles.
• Perform formulation characterization, including particle size and zeta potential measurements, pKa determination, and viscosity assessments.
• Quantify nucleic acids using RiboGreen, NanoDrop spectrophotometry, and other relevant techniques.
• Utilize gel electrophoresis for nucleic acid and protein analysis (including Western blotting).
• Implement and refine nanoparticle purification techniques, such as ultrafiltration and tangential flow filtration (TFF).
• Conduct cell-culture experiments, including transfection of immortalized cell lines with nucleic acids or nucleic acid formulations.
• Set up and conduct high-throughput in vitro screening assays for evaluating formulation effectiveness.
• Support the setup and automation of laboratory protocols, including lab automation equipment setup and programming.
• Participate in animal studies to evaluate drug or vaccine delivery formulations.
• Collaborate with cross-functional teams to troubleshoot and solve technical challenges in formulation and characterization.
• Contribute to the continuous improvement of experimental techniques and methodologies.

Qualifications :

Desired Experience (Not Required for All Candidates) :

What We Offer :

PopVax is committed to creating an inclusive, diverse environment and is proud to be an equal-opportunity employer. We encourage individuals from all backgrounds to apply.

Skills Required

Purification, Hplc, Elisa, Life Sciences, Clinical Trials