Staff Software Engineer

What if the work you did every day could impact the lives of people you know? Or all of humanity?At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

We are looking for an experienced Staff Software Engineer to drive the design and delivery of scalable, secure, and business-aligned solutions across our cloud ecosystem. This role bridges business strategy and technology execution, requiring deep technical proficiency across multiple technologies.

You will work closely with stakeholders to understand business needs and translate them into effective architectural solutions. As a key technical leader, you will guide engineering teams, shape system architecture, and ensure our technology investments support long-term business success.

Responsibilities :

• Lead the design and architecture of cloud-native solutions that align with business objectives and user needs.
• Partner with business units, product managers, UX teams, and engineering to define end-to-end solutions that balance functionality, scalability, performance, and cost-effectiveness.
• Act as the architectural owner across application layers—UI, backend services, APIs, databases, and cloud infrastructure.
• Guide the integration of AI / ML, data engineering, and operational workflows into cohesive business solutions.
• Exposure to or knowledge of BI tools like Power BI and / or Tableau.
• Produce clear architectural documentation, solution proposals, and system blueprints to drive implementation.
• Uphold enterprise standards for security, performance, and maintainability.
• Provide leadership during system troubleshooting and contribute to incident resolution with a holistic architectural perspective.
• Support strategic planning, technical roadmaps, and continuous improvement initiatives in line with business growth.

Preferred Experience / Education / Skills :

Position Summary :

Plans, designs, develops and tests software systems or applications for software enhancements and new products including cloud-based or internet-related tools.

Changes to individual responsibilities may occur due to business needs and other related duties may be assigned.

Scope of Responsibilities :

Experience / Education :

We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact To learn more, visit : . The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.