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Structural Biologist

Structural Biologist

MerilMysore, IN
3 days ago
Job description

Job Description :

  • We are seeking a highly skilled and motivated Structural Biologist to join our drug

discovery programs. The ideal candidate will bring deep expertise in

macromolecular structure determination and modeling, with a focus on elucidating

protein structures, analyzing ligand binding, and driving rational drug design in

collaboration with computational and medicinal chemistry teams.

Key Responsibilities :

  • Analyze protein-ligand interactions to inform medicinal chemistry and lead
  • optimization efforts.

  • Conduct molecular dynamics (MD) simulations and free energy calculations to
  • evaluate complex stability and binding energetics.

  • Apply structural insights to guide hit-to-lead and lead optimization strategies.
  • (Preferred) Utilize machine learning models to support binding site prediction or
  • compound prioritization.

    Required Skills & Experience :

  • Strong expertise in structural biology techniques, such as crystallography, cryo-
  • EM, or NMR are desirable.

  • Proficient in macromolecular modeling and structure refinement tools (e.g.,
  • Phenix, Coot, Chimera, PyMOL).

  • Experience with protein-ligand docking, structure validation, and interaction
  • mapping.

  • Hands-on experience with molecular dynamics simulations using tools such as
  • GROMACS, AMBER, NAMD, or CHARMM.

  • Familiarity with structure-based drug design platforms (e.g., Schrödinger,
  • AutoDock).

  • Scripting or programming experience (Python, R, Bash) for workflow automation and
  • structural data analysis.

    Preferred Qualifications :

  • Ph.D. in Structural Biology, Biophysics, Computational Biology or related field.
  • Demonstrated experience in drug discovery pipelines, especially in target
  • validation and lead optimization.

  • (Preferred) Background in machine learning or AI applied to biomolecular structure
  • or ligand interaction prediction.

  • Strong publication record or demonstrated project impact in therapeutic
  • development.

    What We Offer :

  • Work on high-impact, discovery-stage therapeutic programs.
  • Collaborative and interdisciplinary research environment.
  • Access to state-of-the-art computational and structural biology platforms.
  • Create a job alert for this search

    Structural • Mysore, IN

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