Scientist - Peptide Process R &D

About the job

Job Description

Job Title : Scientist - Peptide Process R &D

( Proven track record in both SPPS and LPPS is highly desirable)

Education & Experience : M.Sc. / PhD Organic chemistry with experience on Peptide Process R &D with 3 to 15 years of experience. .

1.0 Position Summary

We are seeking a highly skilled and motivated Research Scientist specializing in peptide chemistry. The ideal candidate will be responsible for the design, execution, optimization, and scale-up of synthetic peptides using both Solid-Phase Peptide Synthesis (SPPS) and Liquid-Phase Peptide Synthesis (LPPS) methodologies. This role requires hands-on expertise in various synthesis techniques, purification, and analytical characterization, as well as a strong commitment to safety, documentation, and project management within a dynamic R&D environment.

2.0 Key Responsibilities

A. Peptide Synthesis & Development

• Design and execute multi-step synthesis of complex peptides (up to 30-40 mers) using manual and automated SPPS techniques.
• Demonstrate expertise with a wide range of peptide synthesis resins (e.g., 2-CTC, Rink Amide, Wang, Sieber) and select appropriate resins, protecting groups (Fmoc / Boc), coupling reagents, and solvents for target sequences.
• Perform advanced peptide modifications, including disulfide bridging, lactamization, and other cyclization strategies.
• Conduct peptide synthesis in solution phase (LPPS) utilizing both Fmoc and Boc protection strategies.
• Expertly carry out critical downstream processes, including resin cleavage, global deprotection, quenching, and product isolation.

B. Instrumentation & Technology

C. Purification & Analysis

D. Compliance, Safety & Documentation

E. Project Management & Collaboration