▷ [01 / 10 / 2025] Senior Scientist- DMPK ((Large molecule / ADC PK and bioanalysis, ADC characterisation

Desired Profile : M. Pharm (Pharmacology / Pharmaceutical Analysis) / M.Sc. (Biochemistry / Pharmaceutical Chemistry) with 12-15 years or Ph.D. with 5 years’ experience

Job Description, Key Skills and Competencies :

• Expert in designing and executing DMPK studies to support antibody-drug conjugate (ADC) and monoclonal antibody (mAb) programs, from discovery through IND-enabling stages.
• Extensive experience in quantification of biologics including antibodies, therapeutic proteins, ADCs, and peptides using LC-MS / MS, MSD, and ELISA platforms.
• Proficient in advanced bioinformatics tools such as BioPharma Finder, MaxQuant, Spectronaut, and other relevant analytical software.
• Skilled in applying innovative techniques for function-based identification and selection of ADC and mAb lead candidates, with a strong focus on DMPK profiling to ensure safe and effective therapeutic development.
• Experienced in interpreting complex DMPK data and providing actionable insights to cross-functional project teams.
• Actively represent DMPK functions in internal and external meetings, fostering collaboration and strategic alignment.
• Collaborate closely with cross-functional departments to address ADC-related challenges and deliver integrated solutions from target validation to IND submission.
• Accountable for authoring and reviewing SOPs, study protocols, reports, and regulatory documentation to support both GLP and non-GLP studies.
• Strong foundational knowledge of DMPK principles, including PK / PD, toxicology, and translational sciences. Demonstrated capabilities in communication, innovation, and team leadership.

Competencies :