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Scientist -Process Purification Downstream

Scientist -Process Purification Downstream

Enzene Biosciences LtdDelhi, India
4 hours ago
Job description

Position Summary :

We are looking for a highly motivated Scientist – Downstream Purification to lead and execute multiple downstream development projects with moderate supervision. The role reports to the Sr. Principal Scientist and includes managing a team of up to two members. The Scientist will serve as a subject matter expert, drive project execution, support cross-functional interactions, and mentor junior team members to ensure timely and high-quality project delivery.

Key Responsibilities

  • Plan and execute downstream process activities for mammalian and / or microbial recombinant proteins in alignment with project timelines.
  • Lead ground-level experimental planning, execution, data capture, compilation, and interpretation with the reporting manager.
  • Review and guide preparation of technical presentations and project documentation.
  • Represent the department in internal and external project meetings.
  • Draft and review development reports, BPRs, SOPs, EOPs, and IOPs.
  • Support prioritization discussions and provide feasibility inputs for new projects.
  • Troubleshoot technical challenges and collaborate with manufacturing teams for issue resolution.
  • Oversee laboratory operations including equipment upkeep, cleanliness, and compliance.
  • Coordinate with cross-functional teams, vendors, and clients for technical discussions.
  • Ensure adherence to all EHS guidelines for a safe working environment.

Required Skills & Experience

  • Minimum 8 years of hands-on experience in downstream process development for therapeutic proteins or antibodies.
  • Strong expertise in chromatography, depth filtration, centrifugation, UF / DF, and sterile filtration.
  • Experience with QbD-based development, DoE studies, and data analytics tools (preferred).
  • Exposure to scale-up / scale-down studies, technology transfer, and virus clearance studies.
  • Ability to lead small teams and independently analyze, interpret, and present experimental data.
  • Familiarity with protein analytical techniques (protein assays, SDS-PAGE, HPLC, etc.) is an added advantage.
  • Strong technical acumen, problem-solving mindset, and the ability to work in a dynamic, timeline-driven environment.
  • Excellent planning, communication, organizational, and documentation skills.

    • Education : M.Tech / M.Sc (Full Time )

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