Job Overview :
We are seeking a highly motivated Research Associate / Scientist to join our Cell and Gene Therapy (CGT) Projects. The role involves hands-on research in immune cell engineering, process development, and functional characterization of engineered cells, while working closely with cross-functional teams including Preclinical, GMP Manufacturing, Quality, and Regulatory Affairs.
This is an exciting opportunity to contribute to cutting-edge immuno-oncology and Build a good Career into CGT Domain & translational research programs.
Suitable Profiles :
- PhD / M.Sc. / M.Tech in Life Sciences, Biotechnology, Biochemistry, Biology, or related disciplines
- 2–5 years of relevant research experience
- Strong foundation in Immunology, Cell Biology, and Molecular Biology
Roles and Responsibilities
- Design, plan, and perform laboratory experiments related to various immune cell engineering and the development of robust manufacturing processes for cell therapy products.
- Manage and execute immune cell culture and differentiation, including primary cell culture, cell line maintenance, and gene modification techniques (e.g., using lentiviral vectors, CRISPR-Cas9 systems, etc.).
- Prior experience in generation of lentiviral vectors, viral infection of primary cells and advanced molecular biology techniques, including gene editing techniques will be preferred.
- Develop and perform a variety of cellular and molecular assays for the functional characterization and phenotyping of the engineered cells, using flow cytometry, ELISA, qPCR, ddPCR, live-cell imaging, metabolic health assessments and co-culture set-ups for cytotoxicity testing.
- Accurately collect, record, analyze, and interpret experimental data. Use statistical analysis (e.g., Design of Experiments/DoE) to determine critical process parameters.
- Be able to troubleshoot experiments, analyse data and interpret scientific presentations.
- Ensure all research activities comply with regulatory requirements.
- Identify, analyze, and resolve technical issues during research and process development, implementing process improvements.
- Present research findings, project progress, and scientific strategy to stakeholders, potentially including external collaborators or conferences.
- Involve in projecting requirements, interacting with vendors, and engaging in the pipeline of procuring new consumables and equipment required for the project.
- Work closely within highly matrixed, cross-functional teams and mentor junior scientists or research associates to advance company's Cell and Gene therapy pipeline.
- Communicate effectively to interface with internal functional departments to support the workflow of various study-related activities.
- Coordinate with Preclinical, GMP manufacturing, Quality control, Quality assurance and supply chain teams and strictly adhere to project timelines by preserving integrity, accuracy, safety and quality.
- Actively engage in non-GMP validation and IND filing studies.
- Prepare and involve in compliance monitoring inspections and regulatory agency interactions.
Understand systems and process pertaining to sterile practices, work ethics, safety, health and environment.
Competencies
- PhD / M.Sc. / M.Tech in Biology, Biotechnology, Biochemistry, or related fields
- Coursework in Cell Biology, Immunology, Molecular Biology
- Strong expertise in T-cell or NK-cell biology, immuno-oncology, and CGT processes
- Hands-on experience in:
- Aseptic processing
- Flow cytometry
- Live-cell imaging
- qPCR / ddPCR
- Viral transduction
- Molecular biology techniques
- Problem Solving
- Excellent analytical and critical thinking skills to resolve complex scientific and process-related challenges
- Strong written and verbal communication skills
- High attention to detail and organizational abilities
- Ability to work efficiently in a fast-paced, collaborative environment
- Strong documentation and record-keeping skills in line with regulatory and quality standards
Skills Required
Statistical Analysis, Molecular Biology, Immunology, Cell Biology, Flow Cytometry, aseptic processing, design of experiments, QPCR
