Senior Scientist, Systems Medicine

Job Title : Senior Scientist Systems Medicine

Global Career Level : D

Introduction to role :

Are you ready to dive into the world of Systems Medicine and make a significant impact on drug development As a Senior Scientist youll be at the forefront of scientific innovation utilizing systems modeling techniques to drive decisions in drug discovery and development. Your expertise will be pivotal in developing advanced models that facilitate groundbreaking progress in treating complex diseases.

Accountabilities :

• Create expand or refine mathematical models to address drug-discovery and development questions.
• Review analyze and prepare available data for modeling purposes and apply best modeling approaches to enhance project decision-making.
• Develop / apply PKPD / TKTD models to enable translation of findings from preclinical species to humans.
• Develop and utilize mathematical models to enhance quantitative understanding of mechanisms based on literature and in-house data including identifying relevant data for model development optimization and validation.
• Influence experimental design by using available data and appropriate modeling solutions.
• Engage with project teams and present modeling work.
• Contribute to the development and implementation of new modeling and simulation strategies for clinical drug development decisions.
• Stay up-to-date with emerging literature in modeling and simulation sciences.

Essential Skills / Experience :

Desirable Skills / Experience :

Key Relationships to reach solutions :

Internal (to AZ or team)

Clinical Pharmacometricians

Clinical Pharmacolog ists

Statist icians

DMPK M&S experts

Study project and safety Physicians

Translational Scientists

Toxicologists

External (to AZ)

Credibility with academic partners investigators CROs

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca curiosity drives us to explore new scientific frontiers. We are committed to making a difference by fusing data and technology with scientific innovation. Our inclusive environment encourages collaboration across academia biotech and industry empowering us to tackle some of the worlds most complex diseases. With a focus on lifelong learning we offer diverse opportunities for career growth while impacting patients lives globally.

Ready to make an impact Apply now to join our team of innovators!

Date Posted

20-Nov-2025

Closing Date

19-Dec-2025

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds with as wide a range of perspectives as possible and harnessing industry-leading skills. We believe that the more inclusive we are the better our work will be. We welcome and consider applications to join our team from all qualified candidates regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment) as well as work authorization and employment eligibility verification requirements.

Required Experience :

Senior IC

Key Skills

Laboratory Experience,Mammalian Cell Culture,Biochemistry,Assays,Protein Purification,Research Experience,Next Generation Sequencing,Research & Development,cGMP,Cell Culture,Molecular Biology,Flow Cytometry

Employment Type : Full-Time

Experience : years

Vacancy : 1